Historically, entities with a vested interest in a product that critics have suggested is harmful have consistently used research to back their claims that the product is safe. Prominent examples are: tobacco, lead, bisphenol A, and atrazine. Research literature indicates that about 80–90 % of studies with industry affiliation found no harm from the product, while only about 10–20 % of studies without industry affiliation found no harm. In parallel to other historical debates, recent studies examining a possible relationship between (...) mercury exposure and autism spectrum disorder show a similar dichotomy. Studies sponsored and supported by industry or entities with an apparent conflict of interest have most often shown no evidence of harm or no “consistent” evidence of harm, while studies without such affiliations report positive evidence of a Hg/autism association. The potentially causal relationship between Hg exposure and ASD differs from other toxic products since there is a broad coalition of entities for whom a conflict of interest arises. These include influential governmental public health entities, the pharmaceutical industry, and even the coal burning industry. This review includes a systematic literature search of original studies on the potential relationship between Hg and ASD from 1999 to date, finding that of the studies with public health and/or industry affiliation, 86 % reported no relationship between Hg and ASD. However, among studies without public health and/or industry affiliation, only 19 % find no relationship between Hg and ASD. The discrepancy in these results suggests a bias indicative of a conflict of interest. (shrink)

Historically, entities with a vested interest in a product that critics have suggested is harmful have consistently used research to back their claims that the product is safe. Prominent examples are: tobacco, lead, bisphenol A, and atrazine. Research literature indicates that about 80–90% of studies with industry affiliation found no harm from the product, while only about 10–20% of studies without industry affiliation found no harm. In parallel to other historical debates, recent studies examining a possible relationship between mercury exposure (...) and autism spectrum disorder show a similar dichotomy. Studies sponsored and supported by industry or entities with an apparent conflict of interest have most often shown no evidence of harm or no “consistent” evidence of harm, while studies without such affiliations report positive evidence of a Hg/autism association. The potentially causal relationship between Hg exposure and ASD differs from other toxic products since there is a broad coalition of entities for whom a conflict of interest arises. These include influential governmental public health entities, the pharmaceutical industry, and even the coal burning industry. This review includes a systematic literature search of original studies on the potential relationship between Hg and ASD from 1999 to August 2015, finding that of the studies with public health and/or industry affiliation, 86% reported no relationship between Hg and ASD. However, among studies without public health and/or industry affiliation, only 21% find no relationship between Hg and ASD. The discrepancy in these results suggests a bias indicative of a conflict of interest. (shrink)

Consensus around what constitutes researcher conflicts of interest (COIs) and awareness of their influence on our research are two critical steps in ensuring the integrity of our science. In this research, data were collected from individual scholars via 2 surveys 5 years apart and from journals and associations to examine the level of social consensus and moral awareness among scholars, journals, and associations regarding researcher COIs. Although we observed increases in level of social consensus and moral awareness between 2012 and (...) 2017, results still revealed limited agreement about what relationships constitute a COI and limited awareness about the presence of and the ethical issues surrounding COIs. Although all journals and associations we examined supported COI disclosure, most did not provide researchers with detailed COI-related information, guidance, or disclosure tools. Limited social consensus and moral awareness regarding COIs is problematic because it inhibits the recognition, disclosure, and management of COIs and limits ethical decision making. We need to continue and enhance discussions about COIs and aim to create consensus and awareness where we do not have it with the goal of reducing potential scientific misconduct related to COIs. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

This article investigates the claim that some truths are fundamentally or really true — and that other truths are not. Such a distinction can help us reconcile radically minimal metaphysical views with the verities of common sense. I develop an understanding of the distinction whereby Fundamentality is not itself a metaphysical distinction, but rather a device that must be presupposed to express metaphysical distinctions. Drawing on recent work by Rayo on anti-Quinean theories of ontological commitments, I formulate a rigourous theory (...) of the notion. In the final sections, I show how this package dovetails with ' interpretationist' theories of meaning to give sober content to thought that some things — perhaps sets, or gerrymandered mereological sums — can be 'postulated into existence'. (shrink)

This paper examines two puzzles of indeterminacy. The first puzzle concerns the hypothesis that there is a unified phenomenon of indeterminacy. How are we to reconcile this with the apparent diversity of reactions that indeterminacy prompts? The second puzzle focuses narrowly on borderline cases of vague predicates. How are we to account for the lack of theoretical consensus about what the proper reaction to borderline cases is? I suggest (building on work by Maudlin) that the characteristic feature of indeterminacy is (...) alethic normative silence, and use this to explain both plurality and lack of consensus. (shrink)

W.K. Clifford’s famous 1876 essay The Ethics of Belief contains one of the most memorable lines in the history of philosophy: "it is wrong always, everywhere, and for anyone, to believe anything upon insufficient evidence." The challenge to religious belief stemming from this moralized version of evidentialism is still widely discussed today.

Mathematical proofs generally allow for various levels of detail and conciseness, such that they can be adapted for a particular audience or purpose. Using automated reasoning approaches for teaching proof construction in mathematics presupposes that the step size of proofs in such a system is appropriate within the teaching context. This work proposes a framework that supports the granularity analysis of mathematical proofs, to be used in the automated assessment of students' proof attempts and for the presentation of hints and (...) solutions at a suitable pace. Models for granularity are represented by classifiers, which can be generated by hand or inferred from a corpus of sample judgments via machine-learning techniques. This latter procedure is studied by modeling granularity judgments from four experts. The results provide support for the granularity of assertion-level proofs but also illustrate a degree of subjectivity in assessing step size. (shrink)

Um alinhamento responsável à alguma versão do naturalismo filosófico requer a articulação explicita e cuidadosa de um argumento em sua defesa. Em quatro passos, o texto que segue abaixo expande e examina a validade de um argumento que é frequentemente rascunhado em favor do naturalismo. Como veremos, contudo, a versão do naturalismo que esse argumento nos permite é um pouco diferente dos naturalismos filosóficos mais populares.

An alleged moral right to informational privacy assumes that we should have control over information about ourselves. What is the philosophical justification for this control? I think that one prevalent answer to this question—an answer that has to do with the justification of negative rights generally—will not do.

In lieu of an abstract, here is a brief excerpt of the content:98 HISTORY OF PHILOSOPHY quoted in great numbers. The other is Kern's philosophical competence and his skill in handling complex problems. The book is divided into two parts. Part I gives the reader a brief historical survey of Husserl's changing attitudes toward Kant and the neo-Kantians (especially Natorp and ttickert). Indicating the influences which shaped Husserl's thinking during the years of his studies at the universities of Berlin and (...) Vienna, Kern traces Husserl's development throughout his career as a thinker and a writer. But this survey (pp. 1-50) provides merely the general framework within which the intensive and detailed analyses of Part II (pp. 51-424) must be viewed. Two appendices, an extensive bibliography, and a name index complete the work. The detailed discussions of Part II are, of course, the really important contributions to our understanding of Husserl's relation to Kant and the Kantians. As was to be expected, Husserl found in Kant's works formulations of problems and profound insights that he regarded as crucial to any philosophy. At times, however, Husserl was sure that because of mistaken assumptions, insufficiently clarified presuppositions, and methodological deficiencies Kant himself had not fully realized his intentions. Still, it is evident that, in time, Husserl found himself increasingly in sympathy with Kant's postion. In fact, in the end he used Kant's term "transcendental idealism" to designate his own philosophy. In the course of this development, however, Husserl's thinking underwent various changes and reversals. The detailed analyses of them make fascinating reading and are most revelatory of Husserl's own struggles with obtrnsive problems. In Chapter z of Part II (pp. 55-134), the author discusses Husserl's criticism of Kant's positionwKant's conception of the apriori, his strict separation of "sensibility" and "understanding," his presupposition of a "natural world view," his failure to ask sufficiently radical questions concerning the foundations of knowledge, his lack of a proper method of analysis, and his "psychologism." In the course of his own development, however, Husserl modified and, in some respects, even reversed his criticisms of Kant. Chapters ~, m, re and v of Part II, dealing with problems of formal and transcendental logic, with the possibihty of metaphysics on Kantian principles, and with the complex problems of subjectivity, bear witness to the fact that Huseerl often changed his opinion of Kant's work. Of special interest, however, is Chapter vz. It is devoted to a comparison of Husserl's and Kant's "transcendental idealism" and reveals most strikingly the similarities of the two positions. The chapter dealing with Husserl's relation to l~atorp and Rickert, interesting in its own way, is essentially only a footnote, as it were, to the rest of the hook; but it completes the survey. As I said before, this book gives us not only a remarkable insight into the various phases of development in Husserl's thinking and is therefore indispensable to a real understanding of Husserl's intentions and achievements; it also lets us see Kant's philosophy in a new and revealing perspective--both as to its value and it deficiencies. Only a detailed study can do justice to this book. W. H. WF~mMF~STZR Florida State University Ludwig Wittgenstein. Zettel. Edited by G. E. M. Anscombe and G. H. von Wright. Translated by G. E. M. Anscombe. (University of California Press and Basil Blackwell, 1967. Pp. v + 124 [German and English on facing pages]. $6.95.) The paragraphs in this volume, the editors tell us, were collected in a box-file by Wittgenstein from a period beginning in 1929,though the bulk of them come from typescripts dictated between 1945 and 1948. The editors credit Peter Geach with the major work of arrangement. Whoever is responsible did a superlative job, a remark that holds as well for Miss Anscombe's translation. The editors and Mr. Geach have performed an invaluable service to those interested BOOK REVIEWS 99 in Wittgenstein and--quite apart from Wittgensteinian exegesis--in the problems treated in these pages. The philosophical topics are those of the Investigations (PI) and The Remarks on the Foundations o] Mathematir~ (RFM)---e.g., the attack on... (shrink)

On what grounds will the rational man become a Christian? It is often assumed by many, especially non-Christians, that he will become a Christian if and only if he judges that the evidence available to him shows that it is more likely than not that the Christian theological system is true, that, in mathematical terms, on the evidence available to him, the probability of its truth is greater than half. It is the purpose of this paper to investigate whether or (...) not this is a necessary and sufficient condition for the rational man to adopt Christianity. (shrink)

Informed choice is increasingly recognised as important in supporting patient autonomy and ensuring that people are neither deceived nor coerced. In cancer screening the emphasis has shifted away from just promoting the benefits of screening to providing comprehensive information to enable people to make an informed choice. Cancer screening programmes in the UK now have policies in place which state that it is their responsibility to ensure that individuals are making an individual informed choice. There is a need to evaluate (...) whether such policies mean that those people invited for screening are making informed choices, and how comprehensive information affects other variables such as uptake, cost effectiveness, and satisfaction. At the present time, there is no validated measure of informed choice in cancer screening. Such a measure could be used to evaluate the effectiveness of interventions to increase informed choice and levels of informed choice in a population invited for screening. It could encourage health professionals to be accountable. Factors important when measuring informed choice in cancer screening include an individual’s understanding of the limitations of screening, the ability to make an autonomous choice, and the difference between choice and behaviour. (shrink)

In this article we show that it is possible to completely classify the degrees of r.e. bases of r.e. vector spaces in terms of weak truth table degrees. The ideas extend to classify the degrees of complements and splittings. Several ramifications of the classification are discussed, together with an analysis of the structure of the degrees of pairs of r.e. summands of r.e. spaces.

In Ethics and the Limits of Philosophy, Bernard Williams is rather severe on what he thinks of as an ethics of obligation. He has in mind by this Kant and W. D. Ross. For many, obligation seems the very core of ethics and the moral realm, and lives more generally are seen through the prism of this notion. This, according to Williams, flattens out our lives and moral experience and fails to take into account things which are obviously important to (...) our lives. Once we take these things into account, what do we do if they come into conflict with some of our moral obligations, as Williams, in his earlier writings on moral luck, thought to be the case. I want here to explore some of these ideas, in a way that I think harmonious with Williams's general bent though not one that I intend as in any way detailed exegesis of Williams's work. (shrink)

THE PAPER BEGINS BY CONSIDERING THREE ALTERNATIVE DEFINITIONS OF "ANALYTIC," ONE IN TERMS OF LOGICAL TRUTH, ONE IN TERMS OF THE MEANINGS OF WORDS, AND ONE IN TERMS OF SELF-CONTRADICTION OR INCOHERENCE. NEXT, FIVE DEFINITIONS OF "NECESSARY" ARE CONSIDERED, ONE IN TERMS OF ANALYTICITY, AND ONE PICKING OUT THE BROADER KIND OF LOGICAL NECESSITY DISCUSSED BY KRIPKE AND PLANTINGA. FINALLY, THREE DEFINITIONS OF "A PRIORI" ARE CONSIDERED. ONLY ON A FEW OF THESE DEFINITIONS DO THE CATEGORIES OF ANALYTIC, NECESSARY, AND (...) A PRIORI COINCIDE. (shrink)

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

It is rarely, if at all, thought that Socrates committed suicide; but such was the case, or so I want to suggest. My suggestion turns not upon any new interpretation of ancient sources but rather upon seeking a determination of the concept of suicide itself.